Interaction of nanoparticles with endotoxin <i>Importance in nanosafety testing and exploitation for endotoxin binding</i>

نویسندگان

چکیده

The interaction between engineered nanoparticles and the bacterial lipopolysaccharide, or endotoxin, is an event that warrants attention. Endotoxin one of most potent stimulators inflammation immune reactions in human beings, a very common contaminant research labs. In nanotoxicology nanomedicine, presence endotoxin on nanoparticle surface affects their biological properties leading to misinterpretation results. This review discusses importance detecting contamination nanoparticles, focusing current method detection suitability for nanoparticulate materials. Conversely, capacity bind can be enhanced by functionalization with endotoxin-capturing molecules, opening way development novel assays.

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ژورنال

عنوان ژورنال: Nanotoxicology

سال: 2021

ISSN: ['1743-5404', '1743-5390']

DOI: https://doi.org/10.1080/17435390.2021.1898690